Figure 4.

Prognostic relevance of peri- and intratumoral immune cell infiltration in HNSCC patients. The peritumoral infiltration with helper T cells (A) as well as the intratumoral infiltration with (B) cytotoxic T cells, (C) NK cells and (D) M2 macrophages showed a significant correlation with patient overall survival (OS). A higher infiltration of CD4⁺, CD8⁺, and CD56⁺ cells correlated with an improved OS, whereas a higher intratumoral infiltration with CD163⁺ cells correlated with a poorer OS (log-rank test). In the Kaplan-Meier curves, black or grey dots indicate censored survival data.