Table 3.

Adverse events of antithyroid drugs

Common (1.0–5.0%)

Skin rash

Urticaria

Arthralgia, polyarthritis

Fever

Transient mild leukopenia

Rare (0.2–1.0%)

Gastrointestinal

Abnormalities of taste and smell

Agranulocytosis

Very rare (<0.1%)

Aplastic anemia (PTU, CBZ)

Thrombocytopenia (PTU, CBZ)

Vasculitis, lupus-like, ANCA+ (PTU)

Hepatitis (PTU)

Hypoglycemia (anti-insulin Abs; PTU)

Cholestatic jaundice (CBZ/MMI)

PTU, propylthiouracil; MMI, methimazole; CBZ, carbimazole; ANCA, antineutrophil cytoplasmic antibody.