Table 2. Activities and physical parameters of tolprocarb derivatives (part A).

No.	R	PKS-A IC50(μM)	MBI-A MIC (ppm)	RBC-E Index	Tm (°C)	AlogP
1	OCH2CF3	3.05×10−2	0.2	8	132.2	3.51
2	O-i-Pr	9.75×10−2	1	5	132.4	3.30
3	OCH3	1.04×10−1	5	5	112.0	2.54
4	O-i-Bu	4.15×10−2	1	5	117.6	3.75
5	OCH(CH3)CF3	2.05×10−2	1	8	155.9	3.93
6	OCH2Ph	8.30×10−3	0.2	5	134.0	4.32
7	CH3	1.76	500	2	143.9	1.91
8	CF3	5.61×10−1	100	2	151.4	3.03
9	CH2CF3	7.06×10−1	100	1	193.9	2.96
10	CH2CH2CF3	1.64×10−1	5	1	172.0	3.20
11	CH2-p-Cl-Ph	1.82×10−2	0.2	4	190.5	4.28
12	SCH2CH3	4.38×10−2	5	6	128.5	3.23
13	SCH2CF3	6.18×10−2	5	4	122.1	3.86
14	S-i-Bu	3.02×10−2	1	6	109.8	4.10
15	NHCH2CF3	5.66×10−1	100	1	207.7	2.86
16	4-Morpholinyl	2.97×101	>500	0	171.9	1.79