Table 3. Activities and physical parameters of tolprocarb derivatives (part B).

No.	A	R1	R2	PKS-A IC50(μM)	MBI-A MIC (ppm)	RBC-E Index	Tm (°C)	AlogP
1	CH2CF3	i-Pr	H	3.05×10−2	0.2	8	132.2	3.51
2	i-Pr	i-Pr	H	9.75×10−2	1	5	132.4	3.30
17	CH2CF3	H	H	2.01×10−1	5	2	169.3	2.23
18	i-Pr	CH3	CH3	1.39	500	2	110.0	2.50
19	CH2CF3	H	i-Pr	>100	500	2	129.0	3.51
20	i-Pr	H	i-Pr	>100	>500	1	159.7	3.30
21	CH2CF3	n-Pr	H	6.93×10−2	1	3	170.8	3.51
22	CH2CF3	t-Bu	H	2.82×10−2	0.2	12	101.0	4.02
23	CH2CF3	i-Bu	H	4.68×10−1	100	1	147.5	3.84
24	CH2CF3	c-Hex	H	4.32×10−2	1	3	155.0	4.20
25	CH2CF3	COOCH3	H	2.87×10−2	1	3	139.3	2.12
26	CH2CF3	CH2SCH3	H	3.03×10−1	5	2	153.0	2.58
27	i-Pr	CH2SCH3	H	1.65	500	2	162.2	2.36
28	CH2CF3	CH2SOCH3	H	1.04×101	>500	0	153.7	1.44
29	i-Pr	CH2SOCH3	H	>100	>500	0	192.7	1.22