Table 4. Activities and physical parameters of tolprocarb derivatives (part C).
No. | R | PKS-A IC50(μM) | MBI-A MIC (ppm) | RBC-E Index | Tm (°C) | AlogP |
---|---|---|---|---|---|---|
1 | CH3 | 3.05×10−2 | 0.2 | 8 | 132.2 | 3.51 |
30 | H | 1.66×10−1 | 5 | 3 | 124.0 | 3.05 |
31 | CH2CH3 | 1.67×10−2 | 0.2 | 10 | 117.9 | 3.91 |
32 | Cl | 3.23×10−2 | 1 | 4 | 153.9 | 3.57 |
33 | CF3 | 9.82×10−2 | 2.5 | 3 | 154.8 | 3.93 |
34 | COOCH3 | 1.11×10−2 | >500 | 2 | 160.8 | 2.78 |
35 | SO2CH3 | 4.16×10−1 | 100 | 1 | 166.3 | 2.19 |
36 | COOH | >100 | >500 | 0 | 225.0 | 2.75 |