Table 2.
Drug resistance genes in plasmids analyzed
| Plasmid | Resistance gene | Resistance phenotype | Nucleotide position in plasmid | Accessory or backbone region located |
|---|---|---|---|---|
| pP10159-1 | blaSHV-12 | Beta-lactam resistance | 9,324–10,184 | The blaNDM-1 region |
| ble | Bleomycin resistance | 17,458–17,823 | ||
| blaNDM-1 | Beta-lactam resistance | 17,827–18,639 | ||
| pP10159-2 | blaIMP-4 | Beta-lactam resistance | 4,295–5,035 | In823b |
| qnrS1 | Quinolone resistance | 27,662–28,318 | ΔTn6292 | |
| pP10159-3 | blaKPC-2 | Beta-lactam resistance | 7,737–8,618 | ΔTn6296 |
| pP10159-4 | aacA4cr | Quinolone resistance | 85,056–85,655 | The MDR region |
| blaOXA-1 | Beta-lactam resistance | 85,786–86,616 | ||
| catB3 | Phenicol resistance | 86,754–87,386 | ||
| arr3 | Rifampicin resistance | 87,471–87,923 | ||
| qacEΔ1 | Quaternary ammonium compound resistance | 88,146–88,493 | ||
| sul1 | Sulfonamide resistance | 88,487–89,326 | ||
| blaCTX-M-3 | Beta-lactam resistance | 114,790–115,665 | The blaCTX-M-3 region | |
| The ter locus | Tellurium resistance | 116,056–136,305 | The plasmid backbone | |
| pP10159-5 | blaSFO-1 | Beta-lactam resistance | 87,807–88,694 | The MDR region |
| chrA | Chromate resistance | 98,473–99,678 | ||
| mph(A) | Macrolide resistance | 103,297–104,202 | ||
| aacC2 | Aminoglycoside resistance | 105,261–106,121 | ||
| tmrB | Tunicamycin resistance | 106,134–106,676 | ||
| blaTEM-1 | Beta-lactam resistance | 118,230–119,090 | ||
| The mer locus | Mercuric resistance | 120,698–124,660 | ||
| qacEΔ1 | Quaternary ammonium compound resistance | 128,336–128,683 | ||
| sul1 | Sulfonamide resistance | 128,677–129,516 | ||
| armA | Aminoglycoside resistance | 132,848–133,621 | ||
| msr(E) | Macrolide resistance | 135,920–137,395 | ||
| mph(E) | Macrolide resistance | 137,451–138,335 |
Abbreviation: MDR, multi-drug resistant.