Table 2. P2X7-EGFP protein expression in comparison with other P2X7 (reporter) mouse models (Tg(P2rx7 EGFP)FY174Gsat, www.gensat.org, P2rx7hP2RX7 (Metzger et al., 2017).
| Transgenic P2X7-EGFP |
P2X7 reporter (Gensat) |
Humanized P2X7 | |
|---|---|---|---|
| Brain region | Fusion protein | Soluble EGFP | RNA |
| Hippocampus | M (ML+), O, A | N, G | N (CA3+), O, A |
| Cerebral Cort. | M, O, A | N, G | M, O, A |
| Midbrain | M, O | N, G | nd |
| Thalamus | M, O | G | nd |
| Hypothalamus | M, O | N, G | nd |
| Cerebellum | M, O, A, BG (ML+) | N, G, BG (ML+) | O, A |
| Olfactory bulb | M | G | nd |
| Ventricle | EC | nd | nd |
| Corpus callosum | M, O | nd | nd |
A high density of positive cells in a specific area is indicated by +whereas the presence in specific cells or structures is indicated by letters (N, neuron; PC, Purkinje cell; A, astrocyte; M, microglia; O, oligodendrocyte; BG, Bergmann glia; G, glia-like; EC, ependymal cells, ML, molecular layer; GCL, granular cell layer; nd, not determined). Data from the Gensat mouse are according to information given on the gensat web site (www.gensat.org) for fluorescence images listed under confirmed expression veracity.