Table 3. Biotransformation activities of procymidone and PCM-CH2OH in liver S9 of rats, rabbits, monkeys, and human.
| Species | Activity (pmol/min/mg protein)a) (relative activity)b) | |
|---|---|---|
| PCM to Hydroxylated-PCM | Hydroxylated-PCM to Carboxylated-PCM | |
| Rat | 9.8 (1.0) | 1.0 (1.0) |
| Rabbit | 60.7 (6.2) | 26.4 (26.4) |
| Monkey | 30.4 (3.1) | 32.6 (32.6) |
| Human | 36.4 (3.7) | 12.9 (12.9) |
a) Data represent the mean value (n=2). b) Rat data were defined as 1.0.