Table 4. Biotransformation activities of PCM-CH2OH in rat and human hepatocytes.
| Species | Activity (nmol/hr/106 cells)a) (relative activity)b) | |
|---|---|---|
| Hydroxylated-PCM to Carboxylated-PCM | Hydroxylated-PCM to Glucuronide | |
| Rat | 0.16 (1.0) | 0.11 (1.0) |
| Human | 0.34 (2.1) | 0.43 (3.9) |
a) Data represent mean value (n=2). b) Rat data were defined as 1.0.