Table 2.
Comparison of PDMPs, cytokines, and soluble factors between the patients and controls
| Group | Patients
|
Controls
|
||
|---|---|---|---|---|
| Sepsis with DIC | Sepsis without DIC | HM with DIC | Healthy persons | |
| n | 18 | 7 | 15 | 12 |
| PDMP (U/mL) | 26.8±10.2*1 | 19.4±7.5 | 15.3±7.4 | 9.5±2.1 |
| IL-6 (pg/mL) | 559±284*2 | 312±105*1 | 105±24 | 6.8±1.2 |
| TPO (pg/mL) | 1,866±237*2 | 1,244±107*1 | 425±41 | 366±39 |
| HMGB1 (ng/mL) | 35.2±19.8 | 23.6±11.4 | 35.9±20.2 | 7.3±2.5 |
| sVCAM-1 (pg/mL) | 1,632±508 | 1,586±420 | 1,950±411 | 788±196 |
| sP-selectin (pg/mL) | 285±75*1 | 277±96*1 | 214±42 | 183±26 |
| sE-selectin (pg/mL) | 141±76 | 132±41 | 145±39 | 56±12 |
| sL-selectin (pg/mL) | 2,015±622 | 1,865±513 | 1,980±496 | 720±217 |
Notes: Between-group comparisons were analyzed using the Newman–Keuls and Scheffe’s tests. Data are shown as mean ± SD.
Abbreviations: DIC, disseminated intravascular coagulation; IL-6, interleukin-6; HM, hematological malignancy; HMGB1, high-mobility group box 1; PDMP, platelet-derived microparticle; sE-selectin, soluble E-selectin; sL-selectin, soluble L-selectin; sP-selectin, soluble P-selectin; sVCAM-1, soluble vascular cell adhesion molecule-1; TPO, thrombopoietin.