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. 2018 Sep 12;10:3483–3500. doi: 10.2147/CMAR.S167095

Table 1.

IC50 values for 24-hour single-agent and combination treatments in SF7761, SF8628, and SU-DIPG IV cells

Drug treatment IC50 (μM) SF7761 IC50 (μM) SF8628 IC50 (μM) SU-DIPG IV
Palbociclib (0.2–200 µM) 16.55 16.50 8.77
Temsirolimus (0.2–200 µM) 20.88 36.62 16.83
Temsirolimus (0.2–200 µM) + 2 µM palbociclib – – 11.52
Temsirolimus (0.2–200 µM) + 10 µM palbociclib 15.83 24.95 0.16
Temsirolimus (0.2–200 µM) + 12 µM palbociclib 4.82 – 0.002
Temsirolimus (0.2–200 µM) + 15 µM palbociclib 0.89 2.03 0.002
Temsirolimus (0.2–200 µM) + 20 µM palbociclib – 0.001 –
Temsirolimus (0.2–200 µM) + 25 µM palbociclib 0.44 – –