Figure 5.

Schematic explaining the synergistic treatment of ultrasound with targeted liquid fluorocarbon droplets.

Notes: (A) The targeted liquid fluorocarbon droplets selectively adsorb to the cancer cell by the identification of the target. (B)Then the liquid fluorocarbon droplets enter the cancer cells via antibody-mediated endocytosis. (C) Then, vaporization by ultrasound exposure occurs in the tumor cell, resulting in a bigger bubble which induces the death of the tumor cell. Reproduced from Ishijima A, Minamihata K, Yamaguchi S, et al. Selective intracellular vaporisation of antibody-conjugated phase-change nano-droplets in vitro. Sci Rep. 2017;7:44077. Copyright © 2017, Springer Nature.⁶⁴