Figure 6.
Schematic of FUS-induced BBB opening to enhance IL-12 delivery in brain glioma treatment.
Notes: (A) The FUS transducer produces an FUS beam to the brain. (B) The microbubbles in the capillaries of brain tissue oscillate and explode under the FUS, and thus induce BBB opening. Therapeutic molecules such as IL-12 can then be delivered into the brain tumor effectively to trigger local immunological effects to improve the antitumor effect. Reproduced from Alkins R, Burgess A, Kerbel R, Wels WS, Hynynen K, Francia G. Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival. Neuro Oncol. 2016;18(7):974–981.81
Abbreviations: BBB, blood–brain barrier; FUS, focused ultrasound; IL-12, interleukin-12.