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. 2018 Aug 10;27(19):3449–3463. doi: 10.1093/hmg/ddy258

Figure 6.

Figure 6

Effect of satellite cell-specific ablation of MyD88 on interstitial fibrosis in dystrophic muscle. (A) Representative Masson’s trichrome staining photomicrographs showing fibrosis (blue) in the diaphragm and GA muscle of Mdx;MyD88f/f and Mdx;MyD88scko mice. Quantification of percentage area under fibrosis in (B) diaphragm and (C) GA muscle of Mdx;MyD88f/f and Mdx;MyD88scko mice. (D) Representative photomicrographs of transverse sections of GA muscle of Mdx;MyD88f/f and Mdx;MyD88scko mice after immunostaining for Collagen I (green) and Collagen III (red). Relative mRNA levels of (E)Col1a and (F)Col3a1. Scale bar: 20 μm. N = 5 or 6 in each group. Error bars represent s.d. *P-value < 0.05, **P-value < 0.01 and ***P-value < 0.001 from corresponding littermate Mdx;MyD88f/f mice by unpaired t-test.