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. 2018 Aug 10;27(19):3464–3474. doi: 10.1093/hmg/ddy257

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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The influence of genotype upon methylation at the SUPT3H/RUNX2-DMR. Heat map displaying the percentage effect of genotype at rs10948172, rs10948155 and rs62435998, plus all three SNPs combined, at CpG2 to CpG12 in the following: (A) synovium (n = 59 patients), (B) cartilage (n = 30 patients), (C) fat pad (n = 44 patients) and (D) bone (n = 25 patients). The relative contribution of each SNP was calculated using the log worth and incremental R² statistics. The incremental improvement in R² values capturing explained variability was then plotted. Statistical analyses were performed with the aid of SAS JMP Statistical Data Visualization Software.