Figure 5.

 The Frmd4b^Tvrm222 allele suppresses photoreceptor dysplasia caused by ablation of Nrl. The fundus images of 1-month-old Nrl^–/–(A) and Nrl^–/–Frmd4b^{Tvrm222/Tvrm222} (B) mice. Note that the Nrl^–/– retina displays a spotting phenotype while the Nrl^–/–Frmd4b^{Tvrm222/Tvrm222} retina shows a remarkable reduction of the retinal spotting. H&E stained retinal sections from Nrl^–/– (C) and Nrl^–/–Frmd4b^{Tvrm222/Tvrm222} (D) mice. Note a significant reduction in the number of dysplastic lesions in Nrl^−/− mice harboring the Frmd4b^Tvrm222 allele. Scale bar=100μm. Immunofluorescence staining of Nrl^–/– retinal sections with CTNNB1 and TJP1 show fragmentation of the ELM noted by the arrows (E, G). Such breaks were rarely observed in Nrl^–/–Frmd4b^{Tvrm222/Tvrm222} retinas (F, H). Scale bar=20 μm.