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. Author manuscript; available in PMC: 2018 Sep 17.
Published in final edited form as: Cell Rep. 2018 Feb 6;22(6):1545–1559. doi: 10.1016/j.celrep.2018.01.026

Figure 5. Yy1−/−HSCs Exhibit an Aberrant Genetic Network with Corruption of Genes Involved in Cell-Cycle Regulation $$PARABREAKHERE$$RNA-seq-based comparison of gene expression in Yy1+/+ and Yy1−/−sorted HSCs.

Figure 5.

(A) Heatmap depicting statistically significant, differentially expressed upregulated and downregulated genes.

(B) Gene Ontology analysis of genes upregulated in Yy1−/−HSCs. The most enriched biological processes are shown with corresponding FDR values. F, FDR.

(C) GSEA shows that genes involved in cell-cycle progression and G0 to G1 phase entry are enriched in Yy1−/−HSCs.

(D) Relative mRNA expression of genes in Lin−GFP+ bone marrow cells of Yy1+/+ versus Yy1−/−.

(E) Relative mRNA expressions of genes in Lin−GFP+ bone marrow cells of Yy1+/+ + MigR1, Yy1−/−+ YY1, or Yy1−/−+ ΔREPO. Graphs show means ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001.