Figure 1.

Experimental setup to produce lesions in ex vivo tissues on a clinical MR-HIFU system. The setup consisted of a water bath, filled with degassed water and a closed-loop heating coil that circulated heated water to maintain the water bath temperature at 37.5°C. A customdesigned tissue holder was positioned at a fixed distance from the transducer. The water bath was placed on the patient tabletop’s acoustic window. Each tissue sample (45 mm in thickness) was sonicated using a 3×3 grid pattern with 1 mm spacing between foci in either direction.