Figure 2.

Controlled Direct Effects (CDEs) of selected placenta-derived miRNAs in relation to birthweight at gestational age ranging from 29 to 41 weeks. Panel A1, A2, and A3 illustrate the changes in mean birthweight [g] for a 1-SD increment in placental expression miR-1290 when cord blood arsenic exposure is at 25th, 50th, and 75th percentiles, respectively. Panel B, C, and D illustrate the changes in mean birthweight [g] for a 1-SD increment in placental expression of miR-195, miR-328, and miR-489, respectively. Solid black lines surrounded by shaded area represent the effect estimates and 95% confidence intervals. The horizontal blue dashed lines show the reference values and the vertical blue dashed lines represent the gestational age of 37 weeks. Models were adjusted for natural log cord blood arsenic exposure, maternal age, education, enrollment BMI, number of past pregnancies, infant sex, study site and surrogate variables.