Table 3.

Identified polymorphisms in the human kappa opioid receptor gene

					Allelic frequencies
SNP	Variant	Location	Chromosome 8 position NCBI AY168006	refSNPb ID No.	Caucasion (n = 129)	African-American (n = 70)	Hispanic (n = 60)	Asian (n = 19)	Mixed (n = 13)	Total (n = 291)
1	−88C>G	Exon 1	54214007		0	0.029	0	0	0	0.007
2	IVS1113G>A	Intron 1	54213855		0.047	0.088	0.060	0	0.100	0.052
3	IVS1133G>A	Intron 1	54213835		0	0.079	0.017	0	0.038	0.024
4	IVS1339C>T	Intron 1	54213629		0.006	0.092	0.017	0	0.077	0.031
5	36G>T	Exon 2	54213522	rs1051660	0.136	0.157	0.058	0.237	0.077	0.129
6	459C>T	Exon 3	54197430	rs7815824	0.031	0.150	0.067	0	0.038	0.065
7	508C>Ta	Exon 3	54197381		0	0.007	0	0	0	0.002
8	843A>G	Exon 4	54192117	rs702764	0.143	0.486	0.267	0.026	0.308	0.251
9	846C>T	Exon 4	54192114		0.050	0.150	0.033	0	0.077	0.069
10	852C>T	Exon 4	54192108		0	0.007	0	0	0	0.002
11	948C>T	Exon 4	54192012		0.004	0.043	0	0	0	0.012
12	1008C>T	Exon 4	54191952		0	0	0.008	0	0	0.002

^aAmino acid substitution Arg¹⁶⁹Cys (IC loop 2);

^brefSNP ID from Build 116 of dbSNP as of 19 April 2004. SNP, Single nucleotide polymorphism.