Figure 5:

Example illustrating the application of the FEBio angiogenesis plugin. Simulation of a long axis constrained (LAC) vascularized gel. A) At Day 0, the mesh was seeded with initial microvessel fragments. B) At Day 6, the gel was highly perfused by microvessels and has deformed into a ‘neck’ shape as seen in the LAC experiments. C) Full-geometry construction of the gel as predicted by the deformed FE mesh. D) The deformed gel geometry predicted in the simulation closely resembled the shape of long axis constrained vascularized gels at Day 6. (Scale bar 2 mm).