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. 2018 Jul 13;10(7):e2978. doi: 10.7759/cureus.2978

Table 1. Summary of Cases Reviewed in the Literature.

HTN: hypertension; OCPs: oral contraceptive pills; BP: blood pressure.

First Author (Ref.) Year Case Description
Harris [6]   1969   27-year-old female   -No previous history of HTN or renal disease/No family history of HTN -Taking OCPs for 30 months which led to malignant HTN (BP = 220/150) -Within a month, her BP had fallen to 200/110 mm Hg after taking antihypertensive medications and stopped taking OCPs
Zacherle et al. [7   1972   29-year-old female -No previous history of HTN or renal disease/No family history of HTN -First time taking OCP was in 1967 and after one year, BP increased to 220/150, and by stopping OCP and taking antihypertensive medication, high BP dropped to normal after three months. Second time taking OCP was in 1970, and after one year, malignant HTN (BP = 250/190) led to irreversible renal failure
Dunn et al. [8]   1975   26-year-old female   -History of gestational HTN in 1960. Started OCP in 1964 and got malignant HTN (BP = 230/150) in 1966 -High BP was rapidly controlled after discontinuing OCP and taking antihypertensive medications
Weir et al. [4]   1971-1974 A prospective study of 66 women -High systolic BP after one year (between 115.1 +/- 1.3), high diastolic BP at the end of two years -Discontinuance of OCPs resulted in the return of BP to pretreatment levels within three months -No cases of severe or malignant HTN among patients.