Table 2. Phylogenetic sub-lineages and drug susceptibility patterns of Mycobacterium tuberculosis isolates from university students and members of the surrounding community diagnosed with pulmonary tuberculosis in Eastern Ethiopia.
| Studentsa n = 34 | Local Communityb n = 126 | P-Value | ||
|---|---|---|---|---|
| Phylogenetic Sub lineage n (%) |
Ethiopia_3 | 10 (29.4) | 38 (30.2) | 0.074 |
| Ethiopia_4 | 1 (2.9) | 12 (9.5) | ||
| Ethiopia_H37 Rv like | 7 (20.6) | 15 (11.9) | ||
| Delhi/CAS | 7 (20.6) | 29 (23.0) | ||
| Beijing | 0 (0) | 4 (3.2) | ||
| LAM | 1 (2.9) | 6 (4.8) | ||
| Haarlem | 1 (2.9) | 7 (5.6) | ||
| X-type | 0 (0) | 4 (3.2) | ||
| EAI | 0 (0) | 6 (4.8) | ||
| UgandaII | 1 (2.9) | 0 (0) | ||
| URAL | 1 (2.9) | 1 (0.8) | ||
| Not defined | 5 (14.7) | 4 (3.2) | ||
| Streptomycin n (%) |
Resistant | 7 (20.6) | 17 (13.5) | 0.304 |
| Isoniazid n (%) |
Resistant | 6 (17.6) | 15 (11.9) | 0.379 |
| Rifampin n (%) |
Resistant | 0 (0) | 9 (7.1) | 0.109 |
| Ethambutol n (%) |
Resistant | 0 (0) | 9(7.1) | 0.109 |
| Resistance to ≥1 Anti-TB drugs n (%) |
Yes | 11 (32.4) | 37 (29.4) | 0.734 |
| MDR n (%) |
Yes | 0 (0) | 3 (2.4) | 0.364 |
MDR: Multidrug resistant, EAI: East-African Indian; LAM: Latin American Mediterranean;
a. Prevalent culture-positive TB cases diagnosed through active case finding at Haramaya University, Dire Dawa University or Jigjiga University
b. Acid-fast bacilli sputum smear positive pulmonary TB cases diagnosed at Haramaya district hospital (Haramaya), Hiwot Fana specialized university hospital (Harar), Dil Chora hospital (Dire Dawa) or Karamara hospital (Jigjiga)