Table 2. Association of tooth loss to incident liver cancer and chronic liver disease (CLD) mortality in the Nutrition Intervention Trials Cohort, Linxian, China, 1986–2016.
| Incident liver cancer | Chronic liver disease mortality | |||||||
|---|---|---|---|---|---|---|---|---|
| Person-years | N | HRa | 95% CI | N | HRa | 95% CI | ||
| Ever lost a tooth | ||||||||
| No | 187,621 | 87 | 1.00 | referent | 62 | 1.00 | referent | |
| Yes | 464,413 | 283 | 1.10 | (0.84, 1.42) | 228 | 1.01 | (0.78, 1.29) | |
| Number of teeth lost | ||||||||
| 0 | 187,621 | 87 | 1.00 | referent | 62 | 1.00 | referent | |
| 1–3 | 81,929 | 43 | 1.05 | (0.73, 1.51) | 27 | 0.74 | (0.49, 1.10) | |
| 4–6 | 107,152 | 58 | 1.06 | (0.76, 1.49) | 36 | 0.92 | (0.65, 1.28) | |
| 7–10 | 88,568 | 50 | 1.05 | (0.73, 1.51) | 51 | 1.24 | (0.89, 1.71) | |
| 11–20 | 93,649 | 61 | 1.15 | (0.80, 1.64) | 51 | 1.15 | (0.83, 1.60) | |
| 21–32 | 93,116 | 71 | 1.25 | (0.87, 1.79) | 63 | 1.10 | (0.78, 1.55) | |
| p-value for trend | 0.22 | 0.33 | ||||||
| Age-specific tooth lossb | ||||||||
| I | 222,428 | 114 | 1.00 | referent | 81 | 1.00 | referent | |
| II | 130,475 | 92 | 1.20 | (0.90, 1.58) | 65 | 1.08 | (0.82, 1.42) | |
| III | 133,181 | 64 | 0.97 | (0.71, 1.32) | 67 | 1.14 | (0.86, 1.51) | |
| IV | 165,951 | 100 | 1.27 | (0.96, 1.67) | 77 | 1.13 | (0.86, 1.48) | |
| p-value for trend | 0.22 | 0.33 | ||||||
HR = hazard ratio; CI = confidence interval
aEstimated using cox-proportional hazards regression adjusted for age (age (at randomization) and age2 or loess smoothed age-specific predicted quartiles) gender, body mass index, body mass index, education, cigarette smoking, alcohol use, and trial membership
bAge-specific quartiles of tooth loss were estimated using loess regression; p-value for trend using either the number of teeth loss or the quartile of age-specific tooth loss as a continuous covariate