Table 3. Association of tooth loss to incident liver cancer and chronic liver disease (CLD) mortality by gender in the Nutrition Intervention Trials Cohort, Linxian, China, 1986–2016.
| Male | Female | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liver cancer incidence | CLD mortality | Liver cancer incidence | CLD mortality | ||||||||||||
| Person-yrs | N | HRa | 95% CI | N | HRa | 95% CI | Person-yrs | N | HRa | 95% CI | N | HRa | 95% CI | ||
| Ever lost a tooth | |||||||||||||||
| No | 91,668 | 62 | 1.00 | referent | 55 | 1.00 | referent | 95,953 | 25 | 1.00 | referent | 37 | 1.00 | referent | |
| Yes | 175,768 | 159 | 0.98 | (0.71, 1.34) | 145 | 0.96 | (0.69, 1.35) | 288,645 | 124 | 1.35 | (0.86, 2.13) | 171 | 1.05 | (0.72, 1.53) | |
| Number of teeth lost | |||||||||||||||
| 0 | 91,668 | 62 | 1.00 | referent | 55 | 1.00 | referent | 95,953 | 25 | 1.00 | referent | 37 | 1.00 | referent | |
| 1–3 | 38,776 | 29 | 0.97 | (0.62, 1.51) | 20 | 0.74 | (0.44, 1.25) | 43,153 | 14 | 1.20 | (0.62, 2.31) | 13 | 0.72 | (0.38, 1.36) | |
| 4–6 | 45,017 | 34 | 0.92 | (0.60, 1.42) | 34 | 1.00 | (0.65, 1.55) | 62,135 | 24 | 1.37 | (0.78, 2.42) | 23 | 0.80 | (0.47, 1.36) | |
| 7–10 | 32,133 | 31 | 1.02 | (0.65, 1.60) | 35 | 1.27 | (0.82, 1.99) | 56,435 | 19 | 1.14 | (0.62, 2.10) | 35 | 1.19 | (0.74, 1.92) | |
| 11–20 | 30,108 | 32 | 1.02 | (0.65, 1.63) | 26 | 0.90 | (0.54, 1.48) | 63,541 | 29 | 1.43 | (0.80, 2.54) | 50 | 1.34 | (0.84, 2.11) | |
| 21–32 | 29,734 | 33 | 0.99 | (0.61, 1.59) | 30 | 0.94 | (0.57, 1.55) | 63,382 | 38 | 1.78 | (1.00, 3.18) | 50 | 1.24 | (0.76, 2.00) | |
| p-value for trendb | 0.80 | 0.89 | 0.09 | 0.17 | |||||||||||
| Age-specific tooth lossc | |||||||||||||||
| I | 111,824 | 85 | 1.00 | referent | 78 | 1.00 | referent | 110,604 | 29 | 1.00 | referent | 42 | 1.00 | referent | |
| II | 57,851 | 55 | 1.04 | (0.74, 1.47) | 48 | 0.96 | (0.66, 1.38) | 72,624 | 37 | 1.63 | (0.99, 2.69) | 47 | 1.26 | (0.82, 1.92) | |
| III | 49,252 | 37 | 0.94 | (0.64, 1.39) | 40 | 1.10 | (0.75, 1.61) | 83,929 | 27 | 1.11 | (0.66, 1.89) | 47 | 1.25 | (0.82, 1.90) | |
| IV | 48,509 | 44 | 1.08 | (0.75, 1.57) | 34 | 0.90 | (0.60, 1.35) | 117,442 | 56 | 1.64 | (1.04, 2.59) | 72 | 1.37 | (0.93, 2.02) | |
| p-value for trendb | 0.82 | 0.82 | 0.11 | 0.14 | |||||||||||
HR = hazard ratio; CI = confidence interval
aEstimated using cox-proportional hazards regression adjusted for age (age (at randomization) and age2 or loess smoothed age-specific predicted quartiles) gender, body mass index, body mass index, education, cigarette smoking, alcohol use, and trial membership
bp-value of test for trend using either the number of teeth loss or the quartile of age-specific tooth loss as a continuous covariate
cAge-specific quartiles of tooth loss were estimated using loess regression