Table 4. Association of tooth loss to incident liver cancer and chronic liver disease (CLD) mortality by body mass index in the Nutrition Interventions Cohort, Linxian, China, 1986–2016.
| < 23.0 kg/m2 | ≥ 23.0 kg/m2 | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liver cancer incidence | CLD mortality | Liver cancer incidence | CLD mortality | ||||||||||||
| Patient characteristic | Person-yrs | N | HRa | 95% CI | N | HRa | 95% CI | Person-yrs | N | HRa | 95% CI | N | HRa | 95% CI | |
| Ever lost a tooth | |||||||||||||||
| No | 127,833 | 64 | 1.00 | referent | 62 | 1.00 | referent | 59,789 | 23 | 1.00 | referent | 30 | 1.00 | referent | |
| Yes | 341,592 | 209 | 0.99 | (0.73, 1.35) | 228 | 0.99 | (0.73, 1.34) | 122,755 | 74 | 1.43 | (0.87, 2.37) | 88 | 1.04 | (0.66, 1.62) | |
| Number of teeth lost | |||||||||||||||
| 0 | 127,833 | 64 | 1.00 | referent | 62 | 1.00 | referent | 59,789 | 23 | 1.00 | referent | 30 | 1.00 | referent | |
| 1–3 | 57,397 | 28 | 0.88 | (0.56, 1.38) | 27 | 0.86 | (0.54, 1.35) | 24,492 | 15 | 1.61 | (0.84, 3.10) | 6 | 0.45 | (0.19, 1.09) | |
| 4–6 | 76,203 | 45 | 1.06 | (0.72, 1.56) | 36 | 0.81 | (0.54, 1.24) | 30,922 | 13 | 1.06 | (0.53, 2.12) | 21 | 1.17 | (0.66, 2.07) | |
| 7–10 | 63,315 | 34 | 0.91 | (0.59, 1.40) | 51 | 1.26 | (0.86, 1.86) | 25,253 | 16 | 1.57 | (0.81, 3.06) | 19 | 1.15 | (0.63, 2.09) | |
| 11–20 | 71,245 | 47 | 1.05 | (0.70, 1.58) | 51 | 1.03 | (0.69, 1.53) | 22,404 | 14 | 1.45 | (0.71, 2.98) | 25 | 1.48 | (0.83, 2.66) | |
| 21–32 | 73,432 | 55 | 1.10 | (0.73, 1.67) | 63 | 1.11 | (0.74, 1.66) | 19,684 | 16 | 1.78 | (0.86, 3.69) | 17 | 1.04 | (0.53, 2.04) | |
| p-value for trendb | 0.48 | 0.39 | 0.22 | 0.65 | |||||||||||
| Age-specific tooth lossc | |||||||||||||||
| I | 153,271 | 84 | 1.00 | referent | 81 | 1.00 | referent | 69,157 | 30 | 1.00 | referent | 39 | 1.00 | referent | |
| II | 93,436 | 65 | 1.11 | (0.79, 1.54) | 65 | 1.06 | (0.76, 1.47) | 36,972 | 27 | 1.47 | (0.86, 2.51) | 30 | 1.11 | (0.68, 1.81) | |
| III | 96,806 | 51 | 0.98 | (0.69, 1.39) | 67 | 1.21 | (0.87, 1.68) | 36,375 | 13 | 0.93 | (0.48, 1.79) | 20 | 0.94 | (0.54, 1.63) | |
| IV | 125,912 | 73 | 1.14 | (0.82, 1.57) | 77 | 1.10 | (0.80, 1.52) | 40,039 | 27 | 1.71 | (1.00, 2.92) | 29 | 1.20 | (0.73, 1.97) | |
| p-value for trendb | 0.58 | 0.42 | 0.14 | 0.62 | |||||||||||
HR = hazard ratio; CI = confidence interval
aEstimated using cox-proportional hazards regression adjusted for age (age (at randomization) and age2 or loess smoothed age-specific predicted quartiles) sex, body mass index, education, cigarette smoking, alcohol use, and trial membership
bp-value of test for trend using either the number of teeth loss or the quartile of age-specific tooth loss as a continuous covariate
cAge-specific quartiles of tooth loss were estimated using loess regression