Table 1. Key input parameters.
Description of parameter input | Value | References |
---|---|---|
Alcohol use | ||
Prevalence of unhealthy alcohol use (Male/Female) | 9.7%/2% | [29] |
Relative risk of unhealthy alcohol use on condom misuse or non-use | 1.29 | [30] |
Relative risk of unhealthy alcohol use on non-HIV STIs | 1.72 | [30] |
Relative risk of unhealthy alcohol use on non-adherence to ART | 2.33 | [30] |
Sexual risk behaviors | ||
Proportion abstinent (M/F) | 5%/10% | [31–34] |
Proportion monogamous (M/F) | 31%/69% | [34–36] |
Proportion in multiple, concurrent relationships (M/F) | 56%/17% | Assumption |
Proportion who are clients of (men) or who are CSW (female) (M/F) | 8%/4% | [37, 38] |
Frequency of sex acts (per year) | 104 | Assumption |
Duration of relationship | 1y-30y | Assumption |
Median number of concurrent partners- non CSW | 3 | [36] |
Median number of concurrent partners- CSW | 10 | [36] |
Probability of consistent condom use | 56.8% | [39] |
Relative risk of unsafe sex (condom nonuse most or all of the time) if aware of HIV status | 0.47 | [40] |
HIV epidemiology and transmission | ||
Adult HIV prevalence (1997) | 20.9% | [41] |
Probability of transmission per sex act | 0.00011–0.01243 | [42, 43] |
Prevalence of circumcision among adult men | 20% | [39] |
Modifier of male circumcision on F→M HIV transmission per sex act | RR 0.6 | [44] |
Modifier of consistent condom use on HIV transmission per sex act | RR 0.2 | [45] |
Untreated non-HIV STI prevalence | 6% | [46] |
Probability of HIV testing | 40% | [39] |
Probability of linkage to HIV care and treatment | 50.3% | [39] |
Probability of adherence to ART regimen | 84% | [47] |
Intervention effects and costs | ||
Modifier of Intervention on Linkage and Retention | RR 1.48 | RCT |
Outpatient care, per year, no ART (visits, SMS, BCPP, Financial incentives) | $324 | RCT |
On Site CD4+ test available | $26 | RCT |
Utilities | ||
Decrease in utility with ART | 0.053 | [48] |
Utility with CD4+ count < 50 cells/mm3 | 0.69 | [49, 50] |
Utility with CD4+ count between 50 cells/mm3 and 199 cells/mm3 | 0.79 | [50] |
Utility with CD4+ count ≥200 cells/mm3 | 0.83 | [50] |
Other Costs (2015 US$) | ||
Outpatient care, per year, without ART (non-intervention) | $278 | RCT |
Hospitalization costs, per year | $464 | [51] |
First-line ART, monthly | $13 | [52] |
Second-line ART, monthly | $28 | [52] |
Viral load test | $35 | [53] |
CD4+ count test (non-intervention) | $11 | RCT |
Abbreviations: STI, Sexually transmitted infection; CSW, Commercial sex worker; SMS, text messaging; BCPP, Basic care and prevention package