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. 2018 Sep 11;12:2945–2958. doi: 10.2147/DDDT.S166408

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© 2018 Hong et al. This work is published and licensed by Dove Medical Press Limited

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Effects of SSa on epilepsy behaviors in Li-pilocarpine induced SRS.

Notes: (A) Chemical structure of saikosaponin a (SSa). (B) Flow chart of establish Li-pilocarpine induced epilepsy rat model and drugs treatment allocated. (C) Effect of SSa on seizure frequency. (D) Effect of SSa on seizure duration. (E) Effect of SSa on body weights. Data are expressed as means ± SD. **p<0.01 vs control; ^#p<0.05, ^##p<0.01 vs model.

Abbreviations: SRS, spontaneous recurrent seizures; SSa-H, high saikosaponin A; SSa-L, low saikosaponin A; SSa-M, medium saikosaponin A; VPA, valproic acid.