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. 2018 Sep 11;13:5301–5320. doi: 10.2147/IJN.S166219

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© 2018 Casadó et al. This work is published and licensed by Dove Medical Press Limited

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Cytotoxic effect of SN-38 solubilized in dimethyl sulfoxide (DMSO) and encapsulated in liposomes.

Notes: (A) Survival (%) of HeLa cells after treatment with SN-38 encapsulated in SLE liposomes at different molar ratios. (B) Survival (%) of HeLa cells after treatment with SN-38 encapsulated in liposomes with the compositions indicated, at the same lipid/drug molar ratio (20:1) and in DMSO solution. For (A) and (B), cells were incubated for 24 h with the drug and survival was evaluated 3, 24, and 48 h after drug removal by the MTT assay. Cell survival in the presence of the amount of blank liposomes or DMSO in the incubation medium, which would contain the amount of drug to provide all tested SN-38 concentrations, was always between 96% and 98%. Data correspond to mean values ± SD of at least three different experiments.

Abbreviations: SLE, soy bean lipid extract; SN-38, irinotecan metabolite; DOC, DSPC/DOPS/CHOL; DSPC, L-α-distearoyl-phospathidylcholine; DOPS, L-α-dioleoyl-phosphatidylserine; CHOL, cholesterol; EPC, egg yolk phosphatidylcholine.