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. 2018 Sep 11;13:5301–5320. doi: 10.2147/IJN.S166219

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© 2018 Casadó et al. This work is published and licensed by Dove Medical Press Limited

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LDH assay after treatment of HeLa and Caco-2 cells with SN-38.

Notes: HeLa and Caco-2 cells were treated with SN-38lip and SN-38sol formulations. The numbers along the x-axis indicate the SN-38 concentration; 1, 10, and 50 µM. LDH release was measured at 24 (left panels) and 48 h (right panels). The columns represent the mean percentage of cell survival calculated from LDH release and the error bars (±SD) from three independent experiments. Significance was assessed using a Student’s paired t-test; P-values <0.05 (*), <0.03 (**) and <0.02 (***). The data of LDH activity in the culture medium was normalized with the total protein content.

Abbreviations: SN-38sol, irinotecan metabolite solution in DMSO; SN-38lip, irinotecan metabolite in liposomal form.