Table 2.
Univariate and multivariate Cox proportional hazards model for OS and DFS in OSCC patients
| Variables | Univariate
|
Multivariate
|
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| OS | ||||||
| Gender (male vs female) | 1.362 | 0.589–2.003 | 0.597 | |||
| Age (≤55 vs >55) (years) | 1.412 | 0.687–2.056 | 0.548 | |||
| Differentiation (well/moderate vs poor) | 3.783 | 0.671–3.998 | 0.031 | 2.924 | 0.876–4.221 | 0.040 |
| Tumor size, cm (≤5 vs >5) | 1.122 | 0.812–2.673 | 0.821 | |||
| TNM stage (II+III vs I) | 2.765 | 0.991–3.629 | 0.041 | 2.554 | 1.222–3.012 | 0.049 |
| miR-300 expression (high vs low) | 3.887 | 1.245–5.283 | 0.028 | 3.112 | 1.675–4.434 | 0.035 |
| Tobacco usage (yes vs no) | 3.221 | 1.034–4.557 | 0.033 | 2.678 | 1.097–4.553 | 0.045 |
| DFS | ||||||
| Gender (male vs female) | 1.124 | 0.518–2.003 | 0.719 | |||
| Age (≤55 vs >55) | 1.301 | 0.786–2.135 | 0.613 | |||
| Differentiation (well/moderate vs poor) | 2.934 | 0.567–3.786 | 0.045 | 2.345 | 0.433–3.099 | 0.506 |
| Tumor size, cm (≤5 vs >5) | 1.024 | 0.673–2.945 | 0.839 | |||
| TNM stage (II+III vs I) | 3.011 | 1.034–4.562 | 0.035 | 2.997 | 0.984–3.765 | 0.043 |
| miR-300 expression (high vs low) | 3.642 | 1.345–5.128 | 0.025 | 3.423 | 1.212–4.743 | 0.030 |
| Tobacco usage (yes vs no) | 2.988 | 1.174–4.632 | 0.040 | 2.665 | 1.112–4.086 | 0.049 |
Abbreviations: DFS, disease-free survival; HR, hazard ratio; OS, overall survival; OSCC, oral squamous cell carcinoma.