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. 2018 Aug 23;3(16):e120794. doi: 10.1172/jci.insight.120794

Figure 3. Aloxe3 reduces inflammatory signaling and steatosis in hepatocytes.

Figure 3

(A) RNA-seq analysis of the top 9 downregulated genes in primary hepatocytes expressing either β galactosidase or Aloxe3. n = 3 from a single RNA-seq run performed once. The P value for significantly downregulated pathways is demonstrated as (–Log[P value]). (B) Hepatic TG accumulation and (C) IL-1β or TNFα expression in hepatocytes treated with BSA-conjugated fatty acids with or without Aloxe3 expression. n = 4 in B and n = 4 in C, single representative experiments, which were repeated twice with similar results. ***P < 0.001 and ****P < 0.0001 by 2-tailed t testing with Bonferroni-Dunn post hoc correction versus the bracketed comparison group as indicated.