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. 2018 Aug 23;3(16):e120794. doi: 10.1172/jci.insight.120794

Figure 7. Reduced hepatic steatosis correlates with Aloxe3-induced fasting and reduction of de novo lipogenesis.

Figure 7

(A) H&E staining in livers from low-fat or high–trans fat/cholesterol–fed mice overexpressing empty vector or Aloxe3. (B) Hepatic tissue triglyceride quantification in db/db mice overexpressing GFP or Aloxe3 in the presence or absence of GW9662. (C and D) qPCR quantification of expression for oxidative and fasting-response genes (C) and de novo lipogenic genes (D) in db/db mice expressing GFP or Aloxe3 with or without GW9662 administration. Number of mice in each group is: 10, db/db AAV8GFP; 10, db/db AAV8ALOXE3; 10, AAV8ALOXE3 + GW9662. Scale bar: 100 μm. **P < 0.01, or ****P < 0.0001 by 2-tailed t testing with Bonferroni-Dunn post hoc correction versus the bracketed comparison group as indicated.