Figure 9. Insulin sensitization by Aloxe3 requires hepatic PPARγ.

(A) Insulin tolerance testing in WT or PPARγ-LKO mice expressing hepatic GFP or Aloxe3 after chow or Western diet. (B) Quantification of total area under the glucose time curve. **P < 0.01 and ***P < 0.001 by 2-tailed t test with Bonferroni-Dunn post hoc correction between bracketed comparison groups as indicated. Number of mice in each group is: 4, AAV8^GFP Chow; 5, AAV8^GFP WD; 5, AAV8^ALOXE3 WD; and 4, PPARγ-LKO AAV8^ALOXE3 WD.