TABLE 2.
Patient Characteristics
| Study | Number | Age (SD) | Male n (%) | Hypertension n (%) | Hyperlipidemia n (%) | DM n (%) | Smoker n (%) |
|---|---|---|---|---|---|---|---|
| Aihara et al.26 | |||||||
| +PPI | 500 | 68 (±11.0) | 363 (72.6) | 356 (71.2) | 415 (83.0) | 204 (40.8) | 223 (44.6) |
| -PPI | 500 | 69 (±11.0) | 379 (75.8) | 345 (69.0) | 419 (83.8) | 197 (39.4) | 216 (43.2) |
| Burkard et al.35 | |||||||
| +PPI | 109 | 66.5 (±10.5) | 75 (68.8) | 79 (72.5) | 80 (73.4) | 32 (29.4) | 27 (24.8) |
| -PPI | 692 | 63.3 (±11.3) | 553 (79.9) | 450 (65.0) | 525 (75.9) | 119 (17.2) | 206 (29.8) |
| Harja et al.28 | |||||||
| +PPI | 751 | 66 (±11.0) | 463 (61.7) | 548 (73.0) | 591 (78.7) | 225 (30.0) | 160 (21.3) |
| -PPI | 1,902 | 64 (±12.0) | 1,368 (71.9) | 1,237 (65.0) | 1,335 (70.2) | 505 (26.6) | 494 (26.0) |
| Rossini et al.34 | |||||||
| +PPI | 1,158 | 64 (±11.0) | 875 (75.6) | 736 (63.6) | 762 (65.8) | 314 (27.1) | 571 (49.3) |
| -PPI | 170 | 63 (±11.0) | 138 (81.2) | 111 (65.3) | 123 (72.4) | 48 (28.2) | 84 (49.4) |
| Evanchan et al.42 | |||||||
| +PPI | 1,369 | 63.5 (NR) | NR | 837 (61.1) | 850 (62.1) | 630 (46.0) | NR |
| -PPI | 4,425 | 62.9 (NR) | NR | 2,835 (64.1) | 2,734 (61.8) | 1,601 (36.2) | NR |
| Kreutz et al.32 | |||||||
| +PPI | 6,828 | 67.5 (±10.4) | 4,232 (62.0) | 3,454 (50.6) | 4,630 (67.8) | 1,767 (25.9) | NR |
| -PPI | 9,862 | 65.2 (±10.6) | 7290 (73.9) | 4,581 (46.5) | 6,254 (63.4) | 2,238 (22.7) | NR |
| Zairis et al.30 | |||||||
| +PPI | 340 | 62.1 (±10.5) | 280 (82.4) | 173 (50.9) | 226 (66.5) | 102 (30.05) | 169 (49.7) |
| -PPI | 248 | 61.7 (±10.8) | 203 (81.9) | 115 (46.4) | 162 (65.3) | 65 (26.2) | 126 (50.8) |
| Tentzeris et al.33 | |||||||
| +PPI | 691 | 64.1 (±12.4) | 452 (65.4) | 509 (73.7) | 528 (76.4) | 129 (18.7) | 193 (27.9) |
| -PPI | 519 | 64.4 (±11.9) | 377 (72.6) | 406 (78.2) | 400 (77.1) | 135 (26.0) | 120 (23.1) |
| O’Donoghue et al.31 | |||||||
| +PPI | 2,257 | 62 (±8.0) | 1,587 (70.3) | 1,488 (65.9) | 1,274 (56.4) | 547 (24.2) | 828 (36.7) |
| -PPI | 4,538 | 60 (±8.0) | 3,390 (74.7) | 2,883 (63.5) | 2,516 (55.4) | 1,023 (22.5) | 1,755 (38.7) |
| Gupta et al.36 | |||||||
| +PPI | 72 | 61.7 (±1.2) | NR | 55 (76.4) | 48 (66.7) | 26 (36.1) | 18 (25.0) |
| -PPI | 243 | 62 (±0.7) | NR | 166 (68.3) | 146 (60.1) | 73 (30.0) | 81 (33.3) |
| Banerjee et al.27 | |||||||
| +PPI | 867 | 64.5 (±10.3) | 851 (98.2) | 801 (92.4) | 777 (89.6) | 446 (51.4) | 347 (40.0) |
| -PPI | 3,678 | 63.8 (±9.9) | 3,615 (98.3) | 3,269 (88.9) | 3,141 (85.4) | 1,630 (44.3) | 1,428 (38.8) |
| Zou et al.29 | |||||||
| +PPI | 6,188 | 66.2 (±10.2) | 4,548 (73.5) | 4,412 (71.3) | 3,725 (60.2) | 1,597 (25.8) | 1,993 (32.2) |
| -PPI | 1,465 | 65.7 (±10.6) | 1,083 (73.9) | 1,031 (70.4) | 913 (62.3) | 346 (23.6) | 454 (31.0) |
| Total/average | |||||||
| +PPI | 21,130 | 64.1 | 13,726 (69.7)a | 13,448 (63.6) | 13,906 (65.8) | 6,019 (28.5) | 4,529 (35.0)a |
| -PPI | 28,242 | 63.7 | 18,396 (78.0)a | 17,429 (61.7) | 18,668 (66.1) | 7,980 (28.3) | 4,964 (35.6)a |
a Percentages exclude populations without reported outcome.
DM = diabetes mellitus; NR = not reported; +PPI = with proton pump inhibitor; -PPI = without proton pump inhibitor; SD = standard deviation.