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. Author manuscript; available in PMC: 2018 Sep 18.
Published in final edited form as: Curr Opin Immunol. 2018 May 10;53:124–129. doi: 10.1016/j.coi.2018.04.026

Figure 2: Overview of the coordinated activity of Type I (FcγRIIb) and Type II (CD23) FcγRs in the regulation of B cell activation and selection.

Figure 2:

Development of high-affinity IgG responses is determined by the activity of the CD23-FcγRIIb pathway. Engagement of CD23 by sialylated IgG immune complexes upregulates FcγRIIb expression on B cells, which in turn raises the threshold for the B-cell receptor (BCR)-mediated signaling and B-cell selection. Upon CD23 engagement, only B cells with high-affinity BCRs are selected due to the higher levels of FcγRIIb[20,28].