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. 2018 Sep 14;24(34):3884–3897. doi: 10.3748/wjg.v24.i34.3884

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Effects of TAE226, U0126 and Ly294002 treatments, respectively, on the expression of matrix metalloproteins and vascular endothelial growth factor by gelatin zymography experiments and western blot (A), as well as cell invasion by Boyden chamber assay (B and C). Morphological comparison of cells penetrating into the artificial basement membrane is also shown. Scale bars represent 50 μm. ^aP < 0.001 vs control group. Error bars indicate mean ± SD. MMP: Matrix metalloprotein; VEGF: Vascular endothelial growth factor.