Table 2.
Evolution of the clinical characteristics and illness severity scores of patients according to lactate level (≤ 2 or > 2 mmol/L) and normoxia or hyperoxia treatment
| Lactate ≤ 2 mmol/L (n = 167) | Lactate > 2 mmol/L (n = 230) | |||||
|---|---|---|---|---|---|---|
| Normoxia (n = 75) | Hyperoxia (n = 92) | p value | Normoxia (n = 122) | Hyperoxia (n =T108) | p value | |
| Mortality at d28 | 17 (22.7%) | 23 (25.0%) | 0.680¥ | 54 (44.3%) | 62 (57.4%) | 0.054¥ |
| Mortality at d90¥ | 21 (28.0%) | 30 (32.6%) | 0.513¥ | 63 (51.6%) | 64 (59.3%) | 0.171¥ |
| RRT | 14 (18.9%) | 25 (27.8%) | 0.185 | 50 (42.7%) | 44 (41.5%) | 0.853 |
| Days without vasopressor, mean (SD) | 21 (10) | 19 (9) | 0.323 | 14 (12) | 12 (12) | 0.149 |
| Days without mechanical ventilation, mean (SD) | 16 (9) | 13 (10) | 0.04 | 11 (11) | 9 (11) | 0.131 |
| Days without RRT, mean (SD) | 24 (9) | 22 (10) | 0.12 | 16 (12) | 13 (12) | 0.139 |
| Survival at day 28 without organ support, n (%) | 54 (73.0%) | 61 (67.8%) | 0.47 | 58 (49.6%) | 41 (38.7%) | 0.102 |
| SOFA h0 | ||||||
| Mean (SD) | 9.5 (2.5) | 9.6 (2.4) | 0.851 | 10.6 (2.9) | 10.6 (2.8) | 0.987 |
| Median (IQR) | 9 (8–11) | 9 (8–11) | 0.782 | 11 (8–12) | 11 (8–12) | 0.85 |
| n | 75 | 92 | 122 | 108 | ||
| SOFA h24 | ||||||
| Mean (SD) | 9.4 (2.6) | 9.8 (3) | 0.273 | 11.9 (3.3) | 11.6 (3.4) | 0.526 |
| Median (IQR) | 9 (7–11) | 9 (8–12) | 0.335 | 11 (10–14) | 12 (9–14) | 0.693 |
| n | 75 | 89 | 112 | 104 | ||
| SOFA h48 | ||||||
| Mean (SD) | 7.8 (3.3) | 9.6 (3.6) | 0.001 | 10.8 (4.1) | 10.8 (3.6) | 0.962 |
| Median (IQR) | 7 (6–10) | 9 (7–12) | 0.002 | 10 (8–14) | 10 (9–14) | 0.99 |
| n | 71 | 82 | 93 | 80 | ||
| SOFA h72 | ||||||
| Mean (SD) | 6.6 (3.9) | 8.4 (4.4) | 0.008 | 9.9 (4.6) | 9.2 (4.4) | 0.374 |
| Median (IQR) | 6 (4–9) | 8 (5–11) | 0.014 | 10 (6.8–13) | 9 (6–13) | 0.43 |
| n | 65 | 82 | 88 | 71 | ||
| SOFA d4 | ||||||
| Mean (SD) | 6.3 (4.2) | 6.9 (4.4) | 0.436 | 8 (4.7) | 6.9 (3.8) | 0.136 |
| Median (IQR) | 5 (3–8) | 6 (4–10) | 0.396 | 7 (4–11) | 7 (4–9) | 0.29 |
| n | 53 | 67 | 69 | 57 | ||
| SOFA d5 | ||||||
| Mean (SD) | 5.9 (3.9) | 6.1 (3.9) | 0.815 | 8.3 (4.8) | 6.4 (3.9) | 0.024 |
| Median (IQR) | 5.5 (3–8) | 5 (3–8) | 0.819 | 7 (5–11) | 6 (4–9) | 0.044 |
| n | 44 | 63 | 62 | 51 | ||
| SOFA d6 | ||||||
| Mean (SD) | 5.5 (3.8) | 5.8 (3.9) | 0.704 | 7.8 (4.8) | 6.4 (4) | 0.108 |
| Median (IQR) | 6 (3–7) | 4 (3–9) | 0.695 | 7 (4.5–10) | 5.5 (3–9) | 0.155 |
| n | 37 | 55 | 59 | 44 | ||
| SOFA d7 | ||||||
| Mean (SD) | 5.4 (3.6) | 5.8 (4.2) | 0.726 | 8.1 (5) | 4.9 (3.4) | 0.001 |
| Median (IQR) | 5 (3–7) | 5 (3–8) | 1 | 7 (4–10.2) | 4 (2–7) | 0.002 |
| n | 29 | 47 | 48 | 34 | ||
| PaO2 h0 | ||||||
| Mean (SD) | 148.4 (95.1) | 126.4 (63.8) | 0.09 | 170 (105) | 151.1 (82.9) | 0.139 |
| Median (IQR) | 116 (92–172) | 113 (85–144) | 0.289 | 139 (90–202) | 130 (93–184) | 0.295 |
| n | 75 | 92 | 122 | 108 | ||
| PaO2 h12 | ||||||
| Mean (SD) | 97.1 (29.4) | 265.4 (119) | < 0.0001 | 105.8 (44.9) | 274.6 (136) | < 0.0001 |
| Median (IQR) | 89 (75–117) | 273 (172–367) | < 0.0001 | 96 (70–124) | 277 (158–364) | < 0.0001 |
| n | 69 | 86 | 109 | 103 | ||
| PaO2 h24 | ||||||
| Mean (SD) | 89.3 (27.7) | 221.3 (115.8) | < 0.0001 | 101.0 (46.2) | 229.8 (131.8) | < 0.0001 |
| Median (IQR) | 82 (73–98.5) | 211 (133–295) | < 0.0001 | 91 (77–109.2) | 210.5 (119.8–322.8) | < 0.0001 |
| n | 67 | 83 | 100 | 92 | ||
| PaO2 h72 | ||||||
| Mean (SD) | 88.9 (24.7) | 96.5 (54.6) | 0.306 | 88.6 (25.2) | 92.4 (29.4) | 0.431 |
| Median (IQR) | 84 (71–101) | 82 (74–107) | 0.801 | 84.5 (71.8–96.8) | 86 (74–98) | 0.481 |
| n | 55 | 69 | 72 | 61 | ||
For mortality at day 28 and 90, respectively, an analysis in landmark with a log-rank test was used. For survival at day 28 without organ support and/or renal replacement therapy (RRT) a χ2 test was used. For the number of days without vasopressor therapy, without mechanical ventilation, and without RRT, respectively, a Student’s t test was used. ¥ = log-rank test; for mortality at day 28 in patients with a lactate > 2 mmol/L: χ2 test; d day, h hour