Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Sep 17;9(10):938. doi: 10.1038/s41419-018-0970-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a Schematic drawing for lentivirus RPTOR treatment for glucocorticoid-treated mice. b RPTOR treatment reduced the methylprednisolone-induced loss of RPTOR levels. c μCT images of proximal tibiae showed sparse trabecular bone structure upon glucocorticoid treatment, whereas abundant bone microstructure remained in the RPTOR-treated group. Scale bar, 5 mm. d Increasing RPTOR expression alleviated the methylprednisolone-induced loss of BMD, BV/TV, Tb.N, and Tb.Th. e This treatment also retained Atg4, Atg12, LC3-II levels, and LC3-II/LC3-I ratio. f LC3 immunostaining (arrows) in osteoblasts along trabecular bone was decreased upon glucocorticoid treatment, whereas forced RPTOR expression improved LC3 immunoreactivity. Scale bar, 10 μm. Experiments were performed on six mice, and results are expressed as mean ± standard error. Asterisks (*) resemble a significant difference (P < 0.05) vs. vehicle-treated group, and hashtag (#) indicates a distinguishable difference (P < 0.05) between the methylprednisolone-treated group vs. RPTOR group. Veh, vehicle; GC, glucocorticoid