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. 2018 Sep 17;8:13930. doi: 10.1038/s41598-018-32353-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dose-response of pediatric brain tumor and adult glioblastoma ex vivo cells from patient-derived xenografts to HSV G207 or M002 after 72 hours as measured by cytotoxicity assay. Plot at each dose level represents the mean of 4 replicates ± standard deviation. Sensitivity of pediatric brain tumor xenograft cells to G207 (A) and M002 (B). Sensitivity of adult glioblastoma xenograft cells to G207 (C) and M002 (D). In comparison to the pediatric tumor cells, there were significantly more adult tumor cells alive after 72 hours of G207 (p = 0.0002) and M002 (p < 0.0001) infection. MOI, multiplicity of infection; GBM, glioblastoma; EPN, ependymoma; MB, medulloblastoma; sPNET, supratentorial Primitive Neuroectodermal Tumor.