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. 2018 Sep 17;8:13930. doi: 10.1038/s41598-018-32353-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Average dose-response of pediatric brain tumor (all pediatric tumors, pediatric embryonal tumor subset, pediatric glial tumor subset) and adult glioblastoma ex vivo cells from patient-derived xenografts to HSV M002 and G207 after 72 hours as measured by cytotoxicity assay. Plot at each dose level represents the average ± standard deviation of each tumor group. (A) Comparison of adult glioblastoma tumors and all pediatric brain tumors to M002. (B) Comparison of adult glioblastoma tumors and pediatric embryonal tumors to M002. (C) Comparison of adult glioblastoma tumors and pediatric glial tumors to M002.(D) Comparison of pediatric glial and embryonal tumors to M002. (E) Comparison of adult glioblastoma tumors and all pediatric brain tumors to G207. (F) Comparison of adult glioblastoma tumors and pediatric embryonal tumors to G207. (G) Comparison of adult glioblastoma tumors and pediatric glial tumors to G207. (H) Comparison of pediatric glial and embryonal tumors to G207. MOI, multiplicity of infection.