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. 2018 Sep 17;8:13918. doi: 10.1038/s41598-018-32235-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Haematoxylin and eosin stained vessel on the injured side (a) and non-injured side (b). Thirty images acquired at ×40 magnification are stitched to reconstruct an overall image of the vessel for (a) and (b). Significant plaque development is found in the injured side (a). Vasa vasorum on adventitia in the selected region was stained by anti-von Willebrand factor. A large number of vasa vasorums are found in adventitia on the injured side (c), but a few vasa vasorums are found in adventitia on the non-injured side (d).