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. 2018 Sep 17;8:13906. doi: 10.1038/s41598-018-32125-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cardiomyocyte-specific inhibition of sox9b function alters the expression of critical cardiac development genes. (a) Expression of selected genes from hearts isolated from control (Tg(myl7:Gal4VP16;UAS:tRFP)) embryos and embryos with cardiomyocyte-specific loss of sox9b function (Tg(myl7:Gal4VP16;UAS:dnsox9b-2A-tRFP)) at 50 hpf. Expression of each transcript was analyzed using RT-qPCR normalized to actb1. The expression of these genes in control samples was set to 1. Asterisks represent a significant difference in expression between control (light gray) and experimental hearts (dark gray), *p < 0.05 and False Discovery Rate (FDR) < 0.25, n = 4 for each group. Error bars represent standard error of the mean. (b) A schematic depicting the −2.5 kb upstream DNA sequence of genes in panel A shows the locations of SOX8, SOX9, and SOX10 binding sites in this region. The sequence is shown as a solid black line with distance relative to the TSS (arrow) indicated. The position of each oval above or below the sequence refers to the strand each binding site resides on (top = positive strand, bottom = minus strand).