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. 2018 Sep 17;3:36. doi: 10.1038/s41541-018-0075-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Human predicted H56 + IC31 dose vs. IFN-γ response curve at a late time point (day 224) based on the mouse dose ranging data. Red points are the predicted median number of total IFN-γ secreting CD4+ T cells by the IS/ID model for a range of doses. The green vertical dashed line is the most immunogenic dose in the dose–response curve, the value of which is underlined in the x-axis. Each panel shows the results for dose allometric scaling factors of 10, 5 and 1 (for the whole range of scaling factors 1–10, see Figure S10)