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. 2018 Jan 29;15(8):731–733. doi: 10.1038/cmi.2017.139

Figure 1.

Figure 1

Association between host innate immune system and HBV to induce TNF-α. Innate immune system senses HBV core through unidentified sensors and then produces TNF-α. Insufficient TNF-α production and blockade of TNF-α pathway impair HBV clearance and result in its persistence.