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. 2018 Sep 17;8:13894. doi: 10.1038/s41598-018-32297-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) RGS scores increase from baseline (BL) after 3.5N loading on days 1, 3, and 5 (*p < 0.001) and 1 day after the cessation of loading (day 7) (**p = 0.019). However, RGS scores return to baseline levels by day 13 (p = 0.820). The grey line indicates the previously reported analgesic intervention score for the RGS⁴⁶. (B) Head withdrawal thresholds (g) decrease from BL levels both during and after loading on all days (*p < 0.01). The loading period is labeled in (B) and shown in the pink shaded region of both panels.