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. 2018 Sep 17;3:15. doi: 10.1038/s41536-018-0041-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Results of sensitivity analysis representing SMD and 95% CI for the self-reported physical function (WOMAC physical functional score) between pre and post MSC treatment at final follow-up in 2 RCTs with 6 data sets (n = 60). The diamond represents the pooled SMD using the DerSimonian-Laird method. The vertical line at 0 represents no difference. Including only RCTs attenuates the effects of MSC in improving WOMAC functional score (pooled SMD: 0.53, 95% CI: 0.07, 0.99; P = 0.020) compared to those shown in Fig. 3