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. 2018 Sep 11;12:309. doi: 10.3389/fncel.2018.00309

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Copyright © 2018 Fan, Chen, Pathak, Carneiro and Chung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Expression of DAT and PMAT in resting and activated microglia. Quantitative RT-PCR detected mRNA for DAT and PMAT in resting and activated BV₂ microglia. The expression level of DAT increased significantly in activated microglia while PMAT expression decreased. (ANOVA: ^∗P < 0.05 compared to control). (B) Activation of p38MAPK resulted from the activation of microglia by LPS can be blocked by decynium while activation of ERK1/2 can be blocked by spiperone (ANOVA: ^∗∗P < 0.01, ^∗∗∗P < 0.005).