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Model of CAPS1 and CAPS2 function in DRG neurons. Our data suggest that 1. SV exocytosis is promoted by CAPS1 and 2. LDCV exocytosis is mediated by CAPS2 most likely by enhancing priming. 3. Peptidergic cargo released by LDCVs binds to its associated receptor and indirectly induces SV fusion by a yet unknown mechanism. The peptides might act in an autocrine pathway as depicted here or in a paracrine pathway and thereby affect synaptic transmission of many neighboring neurons.
