Table 3.
Groups | Pb levels in liver (μg/g wet tissues) | Pb levels in kidneys (μg/g wet tissues) | Pb levels in brain (μg/g wet tissues) | Pb levels in blood (μg/L) | |
---|---|---|---|---|---|
Intervention groups | Control | 0.37 ± 0.02f | 0.48 ± 0.09d | 0.33 ± 0.05d | 38.60 ± 6.59f |
Pb only | 2.54 ± 0.07a | 4.79 ± 0.28a | 1.91 ± 0.13a | 380.40 ± 28.01a | |
Pb + DSA | 1.44 ± 0.10c | 2.74 ± 0.29b | 1.44 ± 0.15b | 187.67 ± 17.40cd | |
Pb + DSB | 1.40 ± 0.12c | 2.41 ± 0.13b | 1.22 ± 0.10b | 169.22 ± 5.27d | |
Pb + Excipients | 2.51 ± 0.20a | 4.57 ± 0.57a | 2.07 ± 0.17a | 364.37 ± 18.14a | |
DMSA groups | High-dose DMSA | 0.82 ± 0.13e | 1.47 ± 0.14c | 0.74 ± 0.10c | 88.23 ± 12.43e |
Low-dose DMSA | 1.07 ± 0.06d | 1.80 ± 0.25c | 0.94 ± 0.12c | 105.05 ± 6.25e | |
Therapy groups | Control | 0.39 ± 0.03f | 0.53 ± 0.04d | 0.39 ± 0.05d | 35.14 ± 10.40f |
Pb only | 2.51 ± 0.05a | 5.09 ± 0.46a | 1.91 ± 0.06a | 379.40 ± 16.07a | |
Pb + DSA | 1.66 ± 0.06b | 2.89 ± 0.40b | 1.44 ± 0.09b | 213.05 ± 11.56b | |
Pb + DSB | 1.64 ± 0.16b | 2.79 ± 0.34b | 1.33 ± 0.18b | 205.34 ± 13.58bc | |
Pb + Excipients | 2.43 ± 0.08a | 4.50 ± 0.53a | 1.98 ± 0.17a | 364.60 ± 9.93a |
Values are for 10 mice per group. Abbreviations of group names are as in Table 2. a–fStatistically significant differences (P < 0.05) within each group comparison.